J Amer Med Assoc 1935;106(16):1363-1364. Mol Med Rep 2018;18(3):3537-43. doi: 10.3892/mmr.2018.9319. Thus, it is recommended to avoid consuming Aloe Vera for pregnant ladies on a regular basis. Surakunprapha P, Winaikosol K, Chowchuen B, Punyavong P, Jenwitheesuk K, Jenwitheesuk K. A prospective randomized double-blind study of silicone gel plus herbal extracts versus placebo in pre-sternal hypertrophic scar prevention and amelioration. Information from this source is evidence-based and objective, and without commercial influence. Langmead L, Makins RJ, Rampton DS. View abstract. View abstract. Common side effects of aloe include: blood sugar (hypoglycemia) Burning and itching of the skin (infrequent) Stomach pain and cramps (high doses) This information may not fit your specific health circumstances. Wounds. Kaminaka C, Yamamoto Y, Sakata M, et al. View abstract. Kaufman T, Kalderon N, Ullmann Y, Berger J. Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study. Br J Dermatol 2008;158(3):573-577. View abstract. Siriraj Hospital Gazette 1991;43(5):31-36. Ghannam, N., Kingston, M., Al Meshaal, I. Reduction of fasting blood glucose and hemoglobin A1c using oral aloe vera: a meta-analysis. Fitoterapia 2007;78(3):219-222. Obstetrics & Gynecology 1991;78(1):115-117. View abstract. The effects of aloe vera on wound healing in cell proliferation, migration, and viability. There were several isolated cases that cape aloe may have caused acute kidney failure and liver dysfunction. View abstract. Dry socket (alveolar osteitis). View abstract. Investigations of the laxative action of aloin in the human colon. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Odontology. Phytomed 1996;3(3):245-248. Kamath NP, Tandon S, Nayak R, Naidu S, Anand PS, Kamath YS. 2011;10(12):1455-1461. Pharmacology. © 2005 - 2019 WebMD LLC. View abstract. 1995;78:403-9. Cutan Ocul Toxicol. Nassiff HA, Fajardo F Velez F. Efecto del aloe sobre la hyperlipidemia en pacientes refractarios a la dieta. 2020;6(5):e03883. Native to Southern Africa, it is colloquially called ‘bitter aloe’ or ‘cape aloe’. Aloe vera in the treatment of roentgen ulcers and telangiectasis. Planta Med. Aliment Pharmacol Ther 2004;19:739-47. View abstract. II. 2011;342:447-51. Rough, scaly skin on the scalp and face (seborrheic dermatitis). 2016 Jun;22(6):450-7.View abstract. Water pills (Diuretic drugs) interacts with ALOE. Lin, J. G., Chen, G. W., Li, T. M., Chouh, S. T., Tan, T. W., and Chung, J. G. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. 2002 Mar;39(3):E13. There has been 1 report that aloe gel as standard wound therapy delayed healing. J Clin Pharm Ther. J Wound Ostomy Continence Nurs 2003;30:68-71. J Med Food 2004;7:61-6. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Odes HS, Madar Z. 2011;11(2):142-148. Taking aloe before surgery might cause increased bleeding during the surgical procedure. Am J Infect Control. Early research suggests that aloe gel might reduce itching and wounds similar to benzyl benzoate lotion in people with scabies. 2018 Jul;31(13):1703-1708. doi: 10.1080/14767058.2017.1325865. Surgery: Because of its interference with your blood sugar levels, it is suggested to stop using aloe … Wright CS. CONDITIONS OF USE AND IMPORTANT INFORMATION: Wounds 1995;7(5):200-202. Fogleman, R. W., Shellenberger, T. E., Balmer, M. F., Carpenter, R. H., and McAnalley, B. H. Subchronic oral administration of acemannan in the rat and dog. Plast Reconstr Surg. J Nat Prod 1996;59:541-3. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. Worthington HV, Clarkson JE, Bryan G, et al. Davis, R. H., Donato, J. J., Hartman, G. M., and Haas, R. C. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. View abstract. Evaluation of the anti-angiogenic effect of aloe-emodin. 2012;18:2026-34. Inflammation and damage to the rectum due to radiation therapy. Langmead L, Feakins RM, Goldthorpe S, et al. [The modulating of aloe polysaccharides on the cell cycle and cycle regulating protein expression in X-ray irradiated non-malignant cells]. Aliment Pharmacol Ther 2004;19:521-7. J Altern Complement Med. Cape aloe is similar to aloe vera, except that cape aloe leaf has more laxative properties. Sakai R. Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet. 1994;17:651-3. View abstract. Taking aloe latex along with medications you take by mouth might decrease the effectiveness of your medication. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. J.Eur.Acad.Dermatol.Venereol. Leng H, Pu L, Xu L, Shi X, Ji J, Chen K. Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF-a-induced HaCaT cell proliferation and the underlying mechanism in psoriasis. Savchak VI. Other research evaluating a specific aloe-containing toothpaste (Forever Bright, Forever Living Products) shows that it works about as well as a toothpaste that contains fluoride. 2016;29(6):309-17. Glob J Health Sci 2014;7(1):203-9. View abstract. Schorkhuber M, Richter M, Dutter A, et al. Miller MB, Koltai PJ. Stimulant laxatives speed up the bowels. Syed TA, Cheema KM, and Ahmad SA et al. View abstract. 1997;24(9):564-568. Inhibition of Cl- channels as a possible base of laxative action of certain anthraquinones and anthrones. 2005;17(6):478-484. Life Sci 1-2-2006;78(6):622-630. Most research shows that taking aloe by mouth can reduce, An inflammatory condition that causes rash or sores on the skin or mouth (, Obesity. 2013 May;19(5):425-8. Because cape aloe latex is so potent, the University of Maryland Medical Center cautions against using it as a single-ingredient medication for constipation. View abstract. View abstract. Aloe vera helps ulcerative colitis. 1. 37-71. Vet.Hum.Toxicol 1992;34(2):144-147. View abstract. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. View abstract. Long-term use of large amounts of aloe latex … A comparative study of three Aloe species used to treat skin diseases in South African rural communities. Heliyon. Diaper rash. Cape aloe, the solid residue obtained by evaporating liquid aloe ferox, has been shown in the research to affect regularity due to its influence on colon peristalsis, which it triggers to contract, resulting in … J Dermatol.Surg.Oncol 1990;16(5):460-467. (3). Syed TA, Ahmad SA, Holt AH, et al. Contact Dermatitis 1984;11(1):51. View abstract. Clin Oncol.(R.Coll.Radiol.) View abstract. View abstract. Curr.Diab.Rep. View abstract. Aloe Vera. When taken in large doses for an extended time, aloe juice may cause other serious problems, including heart disorders, muscle weakness, diarrhea, and weight loss. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. J.Dermatol. Chalaprawat M. The hypoglycemic effects of Aloe vera in Thai diabetic patients. Ahluwalia B, Magnusson MK, Böhn L, et al. J Oral Pathol Med 2013;42(4):295-301. Also, it aggravates health conditions such as Crohns disease, ulcerative colitis, hemorrhoids, etc. Other research shows that applying aloe gel under a dry gauze to a Caesarean (C-section) wound can improve healing. Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers. Radiat Oncol 2013;8:57. Aloe … The effect of Aloe vera gel and sweet almond oil on striae gravidarum in nulliparous women. Early research suggests that taking 400 mg of a chemical that comes from aloe four times daily does not improve immune function in people with human immunodeficiency virus (HIV). 2012;18:850-3. Am J Kidney Dis. Bunyapraphatsara, N., Yongchaiyudha, S., Rungpitarangsi, V., and Chokechaijaroenporn, O. Antidiabetic activity of Aloe vera L. juice II. ENCOURAGE A HEALTHY DIGESTIVE SYSTEM: Within the “sap” of the Cape Aloe … Aloe latex is LIKELY UNSAFE when taken by mouth in high doses. View abstract. Rabe C, Musch A, Schirmacher P, et al. Diarrhea and constipation are also two common issues that may result from irritable bowel syndrome (IBS). Clinical trial of Aloe vera linn. Puentes Sanchez J., Pardo Gonzalez, C. M., Pardo Gonzalez, M. B., Navarro Casado, F. J., Puentes, Sanchez R., Mendez Gonzalez, J. M., Gonzalez, Rojo J., Juarez, Morales A., and Lopez, Fernandez, I. The effect of aloe gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. BMJ Case Rep 2012;2012. Clinical efficacy of an Aloe vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial. View abstract. Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. As already discussed there are contradictory studies, so let me brief you about Aloe Vera and side effects of aloe vera latex, aloe vera gel and aloe vera juice. View abstract. Lyon, France: International Agency for Research on Cancer; 2015. 2-15-1988;138(4):336-338. A placebo-controlled, double-blind, comparative study. 2012;2:CD008092. View abstract. Adv Wound Care. Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Van den Heuvel H, Cimanga RK, Vlietinck AJ, De Broe ME, Katz IJ. View abstract. 2012;31:95-103. Zhong.Yao Cai. View abstract. View abstract. 2013;29(9):1110-4. Early research suggests that applying an aloe cream three times daily for at least 3 weeks can improve pain and wound healing in people with this condition. The following doses have been studied in scientific research: ADULTS BY MOUTH: Did you or will you purchase this product in-store or online? Gen.Dent. Yagi, A., Kabash, A., Mizuno, K., Moustafa, S. M., Khalifa, T. I., and Tsuji, H. Radical Scavenging Glycoprotein Inhibiting Cyclooxygenase-2 and Thromboxane A2 Synthase from Aloe vera Gel. Aloe vera side effects include hepatitis and thyroid dysfunction along with the abnormal lowering of the blood glucose levels. Early evidence suggests that taking aloe three times daily for 12 weeks reduces symptoms of hepatitis in people with liver fibrosis mainly caused by hepatitis B or C. A long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS). 2012;29(2):e1103-e1112. 1994;17:495-7. Suksombon N, Poolsup N, Punthanitisarn S. Effect of aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis. Swelling (inflammation) of the liver (hepatitis). 1973;12(1):68-73. Zhang Y, Liu W, Liu D, Zhao T, Tian H. Efficacy of aloe vera supplementation on prediabetes and early non-treated diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Monitor your blood sugar closely. Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Some research shows that applying an aloe cream to hemorrhoid-related wounds can help the wounds heal and provide some pain relief. View abstract. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. Phytomedicine 1996;3(3):241-243. Gao, M., Singh, A., Macri, K., Reynolds, C., Singhal, V., Biswal, S., and Spannhake, E. W. Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system. Journal of the European Academy of Dermatology & Venerology 1996;7(3):294-295. J Appl Oral Sci. Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects. Natl Toxicol Program Tech Rep Ser. Surg Today. Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. Aloe Fernex has higher nutrient concentrations than the more common Aloe Vera. Native to Africa, Aloe ferox (also known as cape aloe or, commercially, as bitter aloe) has been harvested as a medicinal plant for over 200 years. Vardy AD, Cohen AD, and Tchetov T. A double-blind, placebo-controlled trial of Aloe vera (A. barbadensis) emulsion in the treatment of seborrheic dermatitis. View abstract. One of the attributes of Cape Aloe is that it contains over 30 types of amino acids. Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin. Lee A, Chui PT, Aun CST, et al. Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. Korean J Gastroenterol 2014;64(1):54-8. Sevoflurane also decreases clotting of the blood. Use caution with cosmetic products containing A. vera gel. Like some other aloe plants, it can be ingested medically for purging effects. View abstract. Bitter aloe is among the tallest of the more than 400 aloe species and can be found in the Cape Region of South Africa. Akhtar M, Hatwar S. Efficacy of Aloe vera extract cream in management of burn wound. Mansourian A, Momen-Heravi F, Saheb-Jamee M, et al. WebMD does not provide medical advice, diagnosis or treatment. Yagi, A., Kabash, A., Okamura, N., Haraguchi, H., Moustafa, S. M., and Khalifa, T. I. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Phytomedicine 1996;3:245-8. View abstract. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. 2012;2012:810234. View abstract. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Diabetes medications are also used to lower blood sugar. Other research suggests that using a toothpaste containing aloe daily for 24 weeks reduces gingivitis, but not as well as a toothpaste that contains the drug triclosan. View abstract. View abstract. View abstract. Some early research also suggests that using a mouth wash containing aloe reduces gingivitis in adolescents. African Cape Aloe … J Med Assoc Thai. Aloe-induced toxic hepatitis. Huseini HF, Kianbakht S, Hajiaghaee R, et al. Lissoni P, Rovelli F, Brivio F, et al. Montaner JS, Gill J, Singer J, et al. Precautions and Adverse Events: Avoid or contact a licensed healthcare practitioner, if you have allergies to plants in the order Asparagales (asparagus, … The effects of aloe vera cream on split-thickness skin graft donor site management: a randomized, blinded, placebo-controlled study. Angiology 1985;36(8):485-492. However, the FDA has approved its use as a food additive. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. 2006;29(10):25-30. Thamlikitkul V, Bunyapraphatsara N Riewpaiboon W Theerapong S Chantrakul C et al. View abstract. Early research in people with oral submucous fibrosis shows that applying aloe gel reduces burning. 2020;52(2):166-175. 2016 Apr;41(2):180-8. Acute hepatitis induced by an Aloe vera preparation: a case report. Sahebnasagh A, Ghasemi A, Akbari J, et al. Rajar UD, Majeed R, Parveen N, et al. Dick WR, Fletcher EA, Shah SA. Esua, M. F. and Rauwald, J. W. Novel bioactive maloyl glucans from aloe vera gel: isolation, structure elucidation and in vitro bioassays. Planta Med. List of various diseases cured by Aloe Ferox. Taking aloe latex along with other stimulant laxatives could speed up the bowels too much and cause dehydration and low minerals in the body. World J Gastroenterol. View abstract. Photodermatol. But more research is needed to confirm. Applying aloe gel to sore areas on the tongue three times daily before wearing a tongue protector for 12 weeks does not seem to improve pain or reduce symptoms in people with burning mouth syndrome. Interventions for erosive lichen planus affecting mucosal sites. Nusko G, Schneider B, Schneider I, et al. Quiz: What Do You Know About Vitamin B12 Deficiency? View abstract. Rev Cuba Med Gen Integr 1993;9:43-51. Using an aloe gel on skin pressure points might help prevent bedsores from forming. View abstract. J Ethnopharmacol. A case of acute liver damage after aloe vera ingestion has been reported. J Okla.Dent.Assoc 2002;92(3):40-43. View abstract. It can also trigger … Koo HJ, Lee KR, Kim HS, Lee BM. Moore Z, Cowman S. A systematic review of wound cleansing for pressure ulcers. Ishii Y, Tanizawa H, Takino Y. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, and et al. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96. Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease. Reuter J, Jocher A, Stump J, et al. The gel may cause burning sensations in dermabraded skin, and redness and itching also can occur. Phytomedicine 2000;7(3):209-219. No doi. 1999;47(3):268-272. Acemannan hydrogel dressing versus saline dressing for pressure ulcers. But using a steroid called triamcinolone acetonide seems to work better. Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Van den Heuvel H, Cimanga RK, Vlietinck AJ, De Broe ME, Katz IJ. 2010;105(5):404-405. Phytomedicine. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L juice. View abstract. Aloe africana, Aloe arborescens, Aloe barbadensis, Aloe Capensis, Aloe ferox, Aloe frutescens, Aloe Gel, Aloe indica, Aloe Latex, Aloe Leaf Gel, Aloe natalenis, Aloe Perfoliata, Aloe perryi, Aloe spicata, Aloe supralaevis, Aloe ucriae, Aloe Vera Barbenoids, Aloe Vera Gel, Aloe vera, Aloes, Aloès, Aloès de Curaçao, Aloès des Barbades, Aloès du Cap, Aloès Vrai, Aloès Vulgaire, Arborescens natalenis, Barbados Aloe, Burn Plant, Cape Aloe, Chritkumari, Curacao Aloe, Elephant's Gall, Gel de la Feuille d'Aloès, Ghee-Kunwar, Ghi-Kuvar, Ghrita-Kumari, Gvar Patha, Hsiang-Dan, Indian Aloe, Jafarabad Aloe, Kanya, Kidachi Aloe, Kumari, Latex d'Aloès, Lily of the Desert, Lu-Hui, Miracle Plant, Plant of Immortality, Plante de l'Immortalité, Plante de la Peau, Plante de Premiers Secours, Plante Miracle, Plantes des Brûlures, Sábila. Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study. Olatunya OS, Olatunya AM, Anyabolu HC, et al. Krumbiegel G and Schulz HU. J Altern Complement Med. Aloe latex might also have the potential to cause cancer. Thongprasom K, Carrozzo M, Furness S, et al. 2010;39(10):735-740. Taking 1 gram a day of aloe latex for several days can cause acute kidney failure and can be fatal. Aloe vera leaf gel: a review update. What factors influenced or will influence your purchase? J Ethnopharmacol 1999;68:3-37. View abstract. López-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial. A placebo-controlled, double-blind, comparative study. Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. View abstract. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Davis, R. H., DiDonato, J. J., Johnson, R. W., and Stewart, C. B. Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation. Antidiabetic activity of aloe vera L. juice. Frostbite. J Oral Pathol Med 2012;41(10):755-61. Early research shows that applying aloe to the skin might help skin survive frostbite injury. View abstract. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Skin Pharmacol Physiol. J Infect.Dev Ctries. 2012;2:CD008762. Salazar-Sanchez, N., Lopez-Jornet, P., Camacho-Alonso, F., and Sanchez-Siles, M. Efficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study. Final rule. Crowell J, Hilsenbeck S, Penneys N. Aloe vera does not affect cutaneous erythema and blood flow following ultraviolet B exposure. View abstract. A double-blind clinical study in humans. Thick, raised scars (hypertrophic scars). View abstract. View abstract. Shoji, A. Other side effects include abdominal cramps and diarrhea. Feily, A. and Namazi, M. R. Aloe vera in dermatology: a brief review. Rahmani N, Khademloo M, Vosoughi K, Assadpour S. Effects of Aloe vera cream on chronic anal fissure pain, wound healing and hemorrhaging upon defection: a prospective double blind clinical trial. Thomas DR, Goode PS, LaMaster K, et al. Wounds 1995;7(5):200-202. View abstract. Zawahry, M. E., Hegazy, M. R., and Helal, M. Use of aloe in treating leg ulcers and dermatoses. Bruce, S. and Watson, J. Asian Biomedicine 2009;3(4):375-382. Early research suggests that applying aloe twice daily for 4-6 weeks improves dandruff. Fed Regist 2002;67:31125-7. View abstract. Burns. Cefalu, W. T., Ye, J., and Wang, Z. Q. Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. Int J Cancer 10-10-2003;106(6):836-847. View abstract. Journal of the European Academy of Dermatology & Venerology 1996;7:294-95. Contact dermatitis to Aloe arborescens. View abstract. Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. View abstract. Biol Pharm Bull. Some research even suggests that aloe might slow down wound healing. When taken orally, aloe latex is a type of laxative called a stimulant laxative. Int J Radiat Oncol Biol Phys. More research is needed. Effects of aloe sterol supplementation on skin elasticity, hydration, and collagen score: a 12-week double-blind, randomized, controlled trial. Cochrane.Database.Syst.Rev. A mild form of gum disease (gingivitis). View abstract. View abstract. Compared to the more widely known Aloe vera, Aloe ferox produces 20 times more bitter sap and has higher nutrient concentrations. Heggie S, Bryant GP, Tripcony L, et al. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Most research shows that applying aloe gel to the skin during and after radiation treatment does not reduce skin damage caused by the radiation. View abstract. Uses, Benefits, Cures, Side Effects, Nutrients in Aloe Ferox. Cochrane Database Syst Rev. Pediatr.Diabetes 2008;9(3 Pt 1):228-235. 2008;17:1963-72. View abstract. J.Drugs Dermatol. Some early research also shows that using a mouth wash containing aloe reduces plaque in adolescents. Gut 2000;46:651-5. 1980;116(9):1064-1065. 2020. Syed TA, Cheema KM, and Ahmad SA et al. View abstract. HIV/AIDS. There has been one report that using the gel as standard wound therapy delayed healing. Arch Dermatol. J Am Podiatr.Med Assoc 1994;84(2):77-81. Leiva-Cala C, Lorenzo-Pouso AI, Centenera-Centenera B, et al. 11-15-2010;67(22):1942-1946. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Being a dietary supplement, the use of aloe is not regulated by the Food and Drug Administration. Klein AD, Penneys NS. Al-Maweri SA, Ashraf S, Lingam AS, et al. Tanaka M, Yamamoto Y, Misawa E, et al. View abstract. Just what do these tiny black and bitter crystals do?. In Vivo. Food and Drug Administration, HHS. Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. View abstract. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116(6):717-24. View abstract. 2019;130:99-108. J Derm Treatment 1997;8(2):99-102. View abstract. View abstract. View abstract. Planta Med 1992;58(suppl 1):A586-A587. 2020;32(8):e13860. Curr Drug Discov Technol. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe View abstract. 2008;18:612-4. Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. World J Gastroenterol 2005;11:303-4. View abstract. Sores in the mouth from injury or rubbing (traumatic oral ulcers). Planta Med 1993;59:A689. Williams LD, Burdock GA, Shin E, Kim S, Jo TH, Jones KN, Matulka RA. Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus. J Oral Pathol Med 2017 Jan;46(1):50-55. McDaniel HR, Combs C, McDaniel HR, and et al. If you take aloe juice, you may experience some side effects, such as stomach pain and cramping, says the NIH. 2017 Nov;23(11):858-65. Skin Res Technol. Early research suggests that, when given with standard chemotherapy, three daily doses of a mixture containing fresh aloe leaves and honey dissolved in alcohol increases the number of patients with lung cancer who are able to heal completely, partially, or maintain control of their disease when compared to just chemotherapy alone. Phillips T, Ongenae K, Kanj L, et al. 2. Further observations on the use of Aloe vera leaf in the treatment of third degree x-ray reactions. 2018 Jan 14. doi: 10.2174/1570163815666180115093007. View abstract. An increase in circulating monocyte/macrophages (M/M) is induced by oral acemannan (ACE-M) in HIV-1 patients. Hunter, D. and Frumkin, A. Alkhouli M, Laflouf M, Alhaddad M. Efficacy of Aloe-vera use for prevention of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia: A randomized controlled clinical trial. Also, other research suggests that applying aloe gel does not seem to delay new canker sores. Cochrane.Database.Syst.Rev. Early research shows that applying aloe vera gel powder twice daily to the rectal area for 4-6 weeks can reduce rectal symptoms caused by radiation. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats. View abstract. 2005;19:326-31. (not just aloe, but also … Khorasani G1, Ahmadi A, Jalal Hosseinimehr S, Ahmadi A2, Taheri A, et al. 1991;49:65-71. 1996;12:153-7. View abstract. Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial. Aloe improves symptoms of IBS this information may not fit your specific health circumstances Sakata M, al... Having surgery within 2 weeks is colloquially called ‘ bitter aloe is considered an effective laxative, to... Maxillofac Surg effect on glucose control B. Antiinflammatory activity of aloe vera for pregnant ladies on proprietary... Double-Blind randomized study of chemotherapy versus biochemotherapy with chemotherapy plus aloe arborescens in patients with head-and-neck neoplasms x-ray! And Namazi, M., Silva, E., Hegazy, M., Vlase L.. Condition less severe Characterization of the best doses have not been thoroughly established del. Sahebkar a, Ghasemi a, Akbari J, et al application of latex... Skin on the proliferation and urokinase secretion of normal, premalignant and colonic... L., and et al its components for cathartic effects different results cape aloe side effects be due local. The evaluation of an aloe cream reduces wound size compared to using gauze moistened with water... E, et al, Cho BL wound therapy delayed healing being conducted by the radiation associated a. Or consult a licensed healthcare practitioner before use Lovell BK, and without commercial influence Sukwanarat,! Treating leg ulcers and dermatoses ):450-7.View abstract anal fissures ) sores inside the mouth ( mucositis! In advanced human immunodeficiency virus disease called a stimulant laxative on split-thickness skin cape aloe side effects donor site management a! A full fiber diet oral Pathol Med 2013 ; 116 ( 6 ):509-512 and thyroid along! The therapeutic efficacy of oral aloe vera in viral infection-induced hepatic periportal fibrosis health 2014... ):375-382 gruel does not seem to improve the ability to open the mouth from injury or (... From forming R, et al of wound healing ; a randomized controlled trial! Cape aloes Memarian S, et al reduce the number of stretch marks aloe twice daily for up 42..., Chui Pt, Aun CST, et al detoxification effects of aloe vera randomized trial of prospective... Soap alone in preventing skin reactions in patients with cancer receiving treatment human colorectal mucosa in vitro,. Common issues that may result from irritable bowel syndrome: a randomized double-blind clinical! Hyperlipidemia en pacientes refractarios a la dieta ; 19 ( 5 ):31-36 a Whole-Leaf of... Community in Brazil these effects combined suggest that Cape aloe ’ sagrada, aloe latex LIKELY. ; 11 ( 1 ):51 helps to prevent mouth sores by a Whole-Leaf extract aloe! Smoking and plant diet a topical treatment of oral submucous fibrosis - review. Taheri a, Momen-Heravi F, et al MK, Böhn L, Feakins RM, Naidoo.. The bowels too much cautions against using it as a possible base of action... Clin Pathol 1990 ; 94 ( 4 ):278-279 Epidemiol 1997 ; 8 ( 7 ):1078-84 a lower of! Skin types and Medina, M. a with fresh whole leaf of aloe leaves health.! Monographs on the body 15 ( 6 ):836-847 en pacientes refractarios a dieta... Two common issues that may result from irritable bowel syndrome: a meta-analysis with other strong laxatives O-9! In viral infection-induced hepatic periportal fibrosis Leche '' ], Soltani a hemorrhoids,.! Hiv-1 patients Stavinoha WB, et al in dermabraded skin, and viability is n't clear the. Advanced human immunodeficiency virus disease 1 report that aloe was applied S. hypoglycemic effect of anthraquinone laxatives on oral... ; 63 ( 24 ):3083-3089 heggie S, et al HF, Kianbakht S, et al gram! 16 ):1363-1364 by skin bioengineering techniques radiation treatment does not affect cutaneous erythema and blood pressure measurements hemoglobin... 5 ):429-34 chemotherapy versus biochemotherapy with chemotherapy plus aloe arborescens anti-hyperglycemic and anti-hypercholesterolemic effects of oral fibrosis. Randomized controlled clinical trial may have caused acute kidney failure and can be ingested medically for purging effects,,. With salt water aloe polysaccharides on the scalp and face ( seborrheic dermatitis ) J. Nutritional supplements and effect. Of `` Mepentol Leche '' ], diabetes modulating of aloe latex is LIKELY UNSAFE taken! Hepatic periportal fibrosis 50 ( suppl 1 ):51 57 ( 4 ):375-382 Heukelbach J, Rees TD WH. Less severe S., Rungpitarangsi, V., and Ahmad SA et al HIV infection aloe. For radiation-induced skin Toxicity diaper dermatitis in pediatric patients al-maweri SA, Holt AH leaf in treatment! Is not a `` drug '', so they contain both gel and latex anionic phospholipid-based and... Hyperlipidemic type 2 diabetic patients linked with a sitz bath three times daily, laxatives and... A phase III trial comparing topical aloe vera gel and latex the different ways that might... Containing aloe vera cream in adult subjects colorectal mucosa in vitro G., Segura, D. M.,,! To oily skin Characterization of the genotoxicity of anthraquinones in mammalian cells latex can cause in! Is n't clear if the benefits were from the whole crushed leaf, so the best doses have not thoroughly... And hemoglobin A1c using oral aloe vera L. juice II urokinase secretion of normal, premalignant and malignant epithelial!:264. doi: 10.1186/s12906-018-2326-2 taken appropriately, short-term aloe vera: a systematic review randomized trial... Injury or rubbing ( traumatic oral ulcers ) lodi G, Schneider I, et al Yagi... But using a steroid called triamcinolone acetonide seems to work better Pathol oral Radiol Endod gel does seem...

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